Table 1 Patient characteristics by tumor deposits in III/IV SRCC in the two cohorts
Characteristic | Training cohort | Validation cohort | ||||
|---|---|---|---|---|---|---|
TD-negative N = 317(%) | TD-positive N = 314(%) | P value | TD-negative N = 79(%) | TD-positive N = 56(%) | P value | |
Age (year) | 0.002 | 0.385 | ||||
≤ 65 | 140(44.2) | 177(56.4) | 47(59.5) | 29(51.8) | ||
> 65 | 177(55.8) | 137(43.6) | 32(40.5) | 27(48.2) | ||
Size | 0.010 | 0.730 | ||||
≤ 5 cm | 158(49.8) | 113(36.0) | 42(53.2) | 28(50.0) | ||
> 5 cm | 159(50.2) | 201(64.0) | 37(46.8) | 28(50.0) | ||
Gender | 0.265 | 0.590 | ||||
Male | 148(46.7) | 161(51.3) | 48(60.8) | 37(66.1) | ||
Female | 169(53.3) | 153(48.7) | 31(39.2) | 19(33.9) | ||
Subsite | 0.188 | 0.337 | ||||
Right | 224(70.7) | 202(64.3) | 22(27.8) | 13(23.3) | ||
Left | 82(25.9) | 102(32.5) | 19(24.1) | 20(35.7) | ||
Rectal | 11(3.4) | 10(3.3) | 38(48.1) | 23(42.1) | ||
Grade | 0.038 | 0.087 | ||||
Well | 21(6.6) | 9(2.9) | 4(5.1) | 0 | ||
Poor | 296(93.4) | 305(97.1) | 75(94.9) | 56(100) | ||
T stage | < 0.001 | 0.159 | ||||
T1-3 | 177(55.8) | 88(28.0) | 39(49.4) | 20(35.7) | ||
T4 | 140(44.2) | 226(72.0) | 40(50.6) | 36(64.3) | ||
N stage | < 0.001 | 0.836 | ||||
< 4 nodes | 112(35.3) | 45(14.3) | 17(21.5) | 13(23.2) | ||
≥ 4 nodes | 205(64.7) | 269(85.7) | 62(78.5) | 43(76.8) | ||
TNM stage | < 0.001 | 0.005 | ||||
III | 249(78.5) | 157(50.0) | 61(77.2) | 30(53.6) | ||
IV | 68(21.5) | 157(50.0) | 18(22.8) | 26(46.4) | ||
PNI | < 0.001 | 0.008 | ||||
Absent | 232(73.2) | 147(46.8) | 50(63.3) | 22(39.3) | ||
Present | 85(26.8) | 167(53.2) | 29(36.7) | 34(60.7) | ||
CEA | 0.008 | 0.487 | ||||
Negative | 153(48.3) | 118(37.6) | 42(53.2) | 26(46.4) | ||
Positive | 164(51.7) | 196(62.4) | 37(46.8) | 30(53.6) | ||
Chemotherapy | 0.074 | 0.455 | ||||
No | 112(35.3) | 90(28.7) | 22(27.8) | 19(33.9) | ||
Yes | 205(64.7) | 224(71.3) | 57(72.2) | 37(66.1) | ||