Table 4 Multivariate analysis of cancer-specific survival and overall survival in the validation cohort
Characteristic | CSS | P value | OS | P value |
|---|---|---|---|---|
Size | ||||
≤ 5 cm | Ref. | Ref. | ||
> 5 cm | 1.13(0.71–1.77) | 0.615 | 1.15(0.74–1.78) | 0.528 |
T stage | ||||
T1-3 | Ref. | Ref. | ||
T4 | 1.59(0.96–2.64) | 0.073 | 1.31(0.83–2.07) | 0.254 |
N stage | ||||
< 4 nodes | Ref. | Ref. | ||
≥ 4 nodes | 1.42(0.77–2.62) | 0.266 | 1.10(0.64–1.87) | 0.737 |
TNM stage | ||||
III | Ref. | Ref. | ||
IV | 1.89(1.15–3.12) | 0.012 | 1.58(0.98–2.53) | 0.061 |
PNI | ||||
Absent | Ref. | Ref. | ||
Present | 1.99(1.18–3.34) | 0.010 | 1.84(1.13-3.00) | 0.014 |
TD | ||||
Negative | Ref. | Ref. | ||
Positive | 1.75(1.04–2.94) | 0.035 | 1.96(1.21–3.18) | 0.006 |
CEA | ||||
Negative | Ref. | Ref. | ||
Positive | 2.04(1.27–3.27) | 0.003 | 1.90(1.23–2.96) | 0.004 |
Chemotherapy | ||||
No | Ref. | Ref. | ||
Yes | 1.21(0.73-2.00) | 0.452 | 1.00(0.63–1.57) | 0.981 |